Thyroid gland cancer and insulin resistance: a modern view of the problem

Background. The impact of insulin resistance on the probability increase in thyroid cancer risk has been drawing a lot attention researchers lately. This problem is far from being completely solved. Studying this interrelationship may influence effectiveness treatment mentioned widespread pathology.
 Purpose – to review present literature sources research between and cancer, also possible mechanisms relationship.
 Materials methods. Literature search was performed manually by keywords (thyroid resistance, IGF-1, IGF-2, abdominal obesity, body mass index, metformin), evidential data bases PubMed, Web Science were reviewed. Metaanalyses, systematic reviews cohort studies taken into account. 148 studied total. sources, which had published within last 10 years, preferably selected.
 Results. Insulin viewed as an important independent factor development numerous malignancies. carcinogenic activity caused itself, well metabolic disorders related it. It established that excessive weight obesity are great extent attributed more aggressive clinical pathological signs cancer. Recent showed larger volume higher knot forming patients with resistance. Thus, one main factors transformation. Therapeutic methods eliminating syndrome associated hormonal diseases for prevention therapy oncologic ever-greater scientific interest. anti-tumor features metformin its capability retarding carcinogenesis shown studies.
 Conclusions. given analysis proved treating malignant tumors their metastasis not only morphological, cellular molecular-biological tumor but insufficient knowledge about high-calorie diet reduction consumption polyunsaturated fats, harmful environment molecular changes, specific confirmed significant rate, especially papillary histotype, alongside rate. studying possibilities decreasing incidence mortality rates pathology when using medications, stabilize contribute decrease degree hyperinsulinemia, metformin, generates profound interest